Women's Health

LUCA Biologics

Indication

Urinary Tract Infection (rUTI)

Modality

Live Biotherapeutic

Status

Phase 1

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Discover

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Mechanism of Action

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Ex VIVO Validation

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Manufacturing

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Scale Up

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IND

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Phase 1

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Phase 2

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Phase 3


Indication

Bacterial Vaginosis (BV)

Modality

Live Biotherapeutic

Status

Manufacturing

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Discover

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Mechanism of Action

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Ex VIVO Validation

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Manufacturing

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Scale Up

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IND

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Phase 1

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Phase 2

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Phase 3


Indication

Spontaneous Preterm Birth (sPTB)

Modality

Live Biotherapeutic

Status

Mechanism of Action

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Discover

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Mechanism of Action

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Ex VIVO Validation

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Manufacturing

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Scale Up

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IND

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Phase 1

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Phase 2

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Phase 3


Neurology

Major Depressive Disorder

Indication

Major Depressive Disorder (MDD)

Status

Discover

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Discover

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Mechanism of Action

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Ex VIVO Validation

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Manufacturing

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Scale Up

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IND

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Phase 1

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Phase 2

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Phase 3


Lipidology

Dyslipidemia (High Cholesterol)

Indication

Hypercholesterolemia; Dyslipidemia

Status

Scale Up

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Discover

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Mechanism of Action

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Ex VIVO Validation

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Manufacturing

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Scale Up

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IND

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Phase 1

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Phase 2

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Phase 3

Citations

1 Eells, S. J., Bharadwa, K., Mckinnell, J. A., & Miller, L. G. (2013). Recurrent Urinary Tract Infections Among Women: Comparative Effectiveness of 5 Prevention and Management Strategies Using a Markov Chain Monte Carlo Model. Clinical Infectious Diseases, 58(2), 147-160. doi:10.1093/cid/cit646

2 Medina, M., & Castillo-Pino, E. (2019). An introduction to the epidemiology and burden of urinary tract infections. Therapeutic advances in urology, 11, 1756287219832172. https://doi.org/10.1177/1756287219832172

3 Koumans, E. H., Sternberg, M., Bruce, C., Mcquillan, G., Kendrick, J., Sutton, M., & Markowitz, L. E. (2007). The Prevalence of Bacterial Vaginosis in the United States, 2001–2004; Associations With Symptoms, Sexual Behaviors, and Reproductive Health. Sexually Transmitted Diseases, 34(11), 864-869. doi:10.1097/olq.0b013e318074e565

4 Peebles, K., Velloza, J., Balkus, J. E., McClelland, R. S., & Barnabas, R. V. (2019). High Global Burden and Costs of Bacterial Vaginosis: A Systematic Review and Meta-Analysis. Sexually transmitted diseases, 46(5), 304–311. https://doi.org/10.1097/OLQ.0000000000000972

5 Witt, W. P., Cheng, E. R., Wisk, L. E., Litzelman, K., Chatterjee, D., Mandell, K., & Wakeel, F. (2014). Preterm Birth in the United States: The Impact of Stressful Life Events Prior to Conception and Maternal Age. American Journal of Public Health, 104(S1). doi:10.2105/ajph.2013.301688

6 Greenberg, P. E., Fournier, A. A., Sisitsky, T., Pike, C. T., & Kessler, R. C. (2015). The economic burden of adults with major depressive disorder in the United States (2005 and 2010). The Journal of clinical psychiatry, 76(2), 155–162. https://doi.org/10.4088/JCP.14m09298

7 Guilbert, J. J. (2003). The World Health Report 2002 - Reducing Risks, Promoting Healthy Life. Education for Health: Change in Learning & Practice, 16(2), 230-230. doi:10.1080/1357628031000116808

8 Tóth, P. P., Potter, D., & Ming, E. E. (2012). Prevalence of lipid abnormalities in the United States: The National Health and Nutrition Examination Survey 2003–2006. Journal of Clinical Lipidology, 6(4), 325-330. doi:10.1016/j.jacl.2012.05.002

9 Indicator Metadata Registry Details. (n.d.). Retrieved from https://www.who.int/data/gho/indicator-metadata-registry/imr-details/3236

10 Daisley, B.A., Pitek, A.P., Chmiel, J.A. et al. Lactobacillus spp. attenuate antibiotic-induced immune and microbiota dysregulation in honey bees. Commun Biol 3, 534 (2020). https://doi.org/10.1038/s42003-020-01259-8

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